Royal Air Force Typhoon FGR4s have conducted a mission with French aircraft in a combined operation on an underground arms cache in Syrian territory used by the IS group, as stated by the UK's MoD.
The site, located using intelligence, was thought to be storing arms and explosives, the statement said, and was positioned in hills just to the north of the historic site of Palmyra in the heart of Syria.
"Our fighter planes utilized precision-guided Paveway IV munitions to hit a number of entry passages providing entry to the site... early reports are that the objective was successfully hit," officials stated.
There was no sign of any civilian casualties in the strike on Saturday evening and all the aircraft returned to base without incident, the defence officials confirmed.
The British jets were supported by a Voyager tanker plane.
IS - also known as Daesh - established extremist governance over parts of Syria and Iraq prior to its 2019 collapse.
"This action underscores the UK's leading role, and commitment to stand shoulder to shoulder with allied nations, to eradicate any re-emergence of IS and their harmful and extremist ideologies in the region," Britain's Defence Chief the minister said.
UK warplanes have performed surveillance missions over Syria to "prevent any attempted comeback" of IS after its routing at the Baghuz confrontation in 2019, the MoD reported.
"I extend gratitude to every member of our armed forces involved in this operation for their skill and their courage," the Defence Secretary said. "They were part of thousands of British troops stationed over Christmas and New Year. This mission, to eliminate dangerous terrorists who pose a risk to our safety, highlights how British military are always on standby, all year round, protecting the UK within its borders and powerful internationally."
Last December, the American forces executed what it termed a "large-scale strike" on Islamic State objectives in Syria, after an assault claimed the lives of two US troops and a civilian interpreter in the Palmyra area.
The UN says Daesh still boasts an estimated 5,000 to 7,000 combatants in Iraq and Syria.
